Cannabidiol (CBD) is a non-intoxicating cannabinoid in the cannabis plant. It is one of at least 113 cannabinoids found in the cannabis plant. The most abundant compound in hemp, CBD, has none of the psychoactive properties of the THC molecule that is dominant in “marijuana.” Cannabinoids are unique because they act on cannabinoid receptors that are part of the endocannabinoid system found in our bodies.

CBD is non-psychoactive and research is showing a number of potential benefits for our mental and physical health. CBD users anecdotally have noted the following common use cases and effects: increasing relaxation, supporting alertness and mental clarity, reducing pain and inflammation, promoting sleep, reducing anxiety and stress, and suppressing nausea.

Both hemp and ‘marijuana’ are part of the cannabis genus of plants. They can be of the same or different species (cannabis sativa, indica or ruderalis) within the cannabis genus. If they are of the same plant species, they will be different varietals: hemp will generally a higher concentration of CBD and a legally-mandated miniscule amount of THC while marijuana will have a high concentration of THC and a relatively smaller concentration of CBD.

“Hemp” is a legal definition of the cannabis plant which requires that the plant has no more than 0.3% THC on a dry weight basis (meaning, after the plant has been cultivated and is dried). For example, if a hemp plant weighs 1 pound after it is dried, then the amount of THC cannot be more than 0.003 pounds or .048 ounces.  And, if the cannabis plant has more than 0.3% THC, then it cannot meet the legal definition of hemp.

Marijuana is a non-legal slang term for cannabis that has been bred for the plant’s psychoactive molecule: THC. THC-rich cannabis plants can have levels of THC up 20%-30% of the plant’s dry weight.

Yes, hemp-derived CBD is fully federally legal. The Agricultural Act of 2018 (aka the 2018 Farm Bill) legalized hemp and hemp-derived products, provided those products do not contain more than 0.3% THC. This means that CBD derived from hemp is no longer part of the Controlled Substances Act of 1970 which previously treated both THC and CBD as Schedule 1 drugs.

No, the 2018 Farm Bill legalized hemp and hemp extracts only. Currently the Controlled Substances Act of 1970 treats what is socially called marijuana and THC or CBD derived from marijuana as Schedule 1 drugs and are therefore federally illegal still.  

No, research has shown the hemp-derived CBD that contains less than 0.3% THC does not produce psychoactive “euphoric” effects. Hemp-derived CBD has a number of potential health benefits and some users describe it as “relaxing without being intoxicating.”


Research on CBD’s effect on a wide range of conditions, including chronic pain, insomnia, PTSD, anxiety, epilepsy, sleeplessness, dementia, etc., has been conducted or is currently taking place. Both preclinical and clinical studies have shown that CBD has strong anti-oxidant, anti-inflammatory, anti-convulsant, anti-depressant, antipsychotic, anti-tumoral, and neuroprotective qualities. Sources: Fasinu PS, Phillips S, ElSohly MA, Walker LA. Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents. Pharmacotherapy 2016;36(7):781-96. Campos AC, Fogaça MV, Scarante FF, Joca SRL, Sales AJ, Gomes FV, Sonego AB, Rodrigues NS, Galve-Roperh I, Guimarães FS. Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders. Front Pharmacol. 2017 May 23;8:269.

Most research has concluded that CBD is not usually associated with side effects, though some users have reported drowsiness, lightheadedness, and dry mouth. The World Health Organization has concluded that CBD is not addictive. To date, there is no evidence of recreational use of CBD or any public health-related problems associated with the use of pure CBD. Even chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. Source: World Health Organization, WHO Expert Committee on Drug Dependence, Thirty-ninth Meeting Geneva, 6-10 November 2017. Safety and side effects of cannabidiol (NCBI/NIH). Curr Drug Saf. 2011 Sep 1;6(4):237-49.  Safety and side effects of cannabidiol, a Cannabis sativa constituent. Bergamaschi MM(1), Queiroz RH, Zuardi AW, Crippa JA

High quality hemp-derived CBD products should be safe if properly manufactured. Consumers should ensure that CBD products are produced in federally regulated facilities that are Consumer Good Manufacturing Practices (cGMP) certified. Consumers should also check their products have a recent certificate of analysis to show the exact amount of cannabinoids in the product and to ensure it is free of pesticides, metals and other harmful materials. We are diligent to ensure that all Core Botanics products meet these high standards.

The entourage effect is the wholistic effect produced by keeping all of the natural compounds in the cannabis plant, such as the cannabinoids, terpenes, and flavonoids. These compounds have been shown to work better when they are taken together. Products that are full spectrum contain CBD as well as other cannabinoids, while CBD isolate is nearly pure CBD without other cannabinoids and cannabis compounds.

CBD is a cannabinoid and cannabinoids are compounds derived from the hemp plant. They work by imitating compounds our bodies naturally produce, called endocannabinoids, that affect nerve, brain and immune cell activity.

Cannabinoids bind to our body’s cannabinoid receptors. There are two primary cannabinoid receptors: CB1 and CB2 receptors. CB1 receptors are generally located in the central nervous system. They affect appetite, muscle control, pain, cognition, thermoregulation, and our stress response. CB2 receptors are primarily found in immune cells, and at a lower density in the central nervous system. CB2 activation is associated with immune function and immune cell proliferation, inflammation, and pain.

Source: Szaflarski JP, Bebin EM, Cannabis, cannabidiol, and epilepsy–from receptors to clinical response. Epilepsy Behav. 2014;41:277-82

The endocannabinoid system is the collection of cannabinoid receptors, endocannabinoids (cannabinoids produced naturally in our bodies) and enzymes involved in producing and breaking down endocannabinoids. It is an integral part of our neuro-immuno-endocrine network. This system affects many aspects of human health including mood, pain, inflammation, stress responses and immune functionality.

The two most studied endocannabinoids are anandamide and 2-AG. The two most studied cannabinoid receptors are CB1 and CB2. CB1 receptors are located mostly in the brain and CB2 receptors are located mostly throughout the immune system. A “phytocannabinoid” or plant-derived cannabinoid like CBD can activate the same receptors in the body and may have similar or stronger effects than the endocannabinoids that our bodies produce naturally.

Endocannabinoids (cannabinoids produced naturally in the body of mammals) are not neurotransmitters. Endocannabinoids are neuromodulators – they are released on demand to alter the activity of neurotransmitters. A good example is glutamate. Glutamate is a primary, stimulatory neurotransmitter. When glutamate is present in excessive amounts, pain and cell death can occur. The release of endocannabinoids functions as a stopping mechanism for the release of glutamate. CBD can act in the same way as our own endocannabinoids.

Hemp extract is the raw extracted material produced from hemp after it undergoes the initial extraction process. The hemp extract is refined over multiple stages and then purified (during which THC may be also removed) to become a CBD product such as a CBD oil tincture.

CBD isolate, or otherwise known as “pure CBD” or “99% CBD”, is the CBD molecule separated from all of the other compounds in the hemp plant. CBD isolate usually appears as a crystalline white powder. CBD isolate is considered to be less effective therapeutically than whole plant CBD-rich oil. It is believed that the aggregation of compounds from the hemp plant produces CBD product’s healing effects through complementary action. This is known as the “entourage effect”, where mixtures of cannabinoids, hemp terpenes, and perhaps other molecules such as flavonoids and stilbenoids, have a greater positive effect than just isolated CBD compounds alone.

Sources: Spelman K. “Silver Bullet” Drugs vs. Traditional Herbal Remedies: Perspectives on Malaria. HG J Am Bot Coun 84:44-55.  Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011 Aug;163(7):1344-64.  Shimon Ben-Shabat S, Fride E, Sheskin T,Tamiri T, Rhee MH, Vogel Z. Bisogno T,De Petrocellis LD, Di Marzo V, Mechoulam R. An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. Euro J Pharmacol. 1998;353:23–31.

Terpenes are essential oils found in plants. There are around 200 terpenes in cannabis. They are what give cannabis its distinct aroma and flavor. Terpenes may have beneficial effects and work synergistically with cannabinoids like CBD to create the entourage effect.

Before you purchase a CBD product, you should ensure that the CBD product was produced in federally regulated facility that is Consumer Good Manufacturing Practices (cGMP) certified. If the CBD product’s seller does not provide that information, then buyer beware. Consumers should also check that the CBD products have recent certificate of analysis (“COA”) to show the exact amount of cannabinoids in the product and to ensure it is free of pesticides, metals and other harmful materials. Again, the seller does not provide this information, there is likely a reason why they are not providing it. Please be wary of such sellers. Lastly, we recommend that you consult with your medical practitioner about taking CBD.

CBD’s effectiveness and the time it takes to affect your body will be dependent on a number of factors unique to you (such as your weight, age, etc).

Generally speaking, however, nanoized water soluble CBD has the fastest affect on the body. What is known as “bioavailability”, Core Botanic’s nanoized water soluble products take effect approximately 5x faster than non-nanoized water soluble CBD products.

Regular CBD products that lack nanoized water soluble CBD will take longer to be absorbed into the body’s bloodstream and therefore to take effect. However, these products generally affect the body depending on how CBD is consumed:

  • Fastest: vaping
  • Fast: sublingual dosage
  • Average: topical administration of CBD lotion or cream
  • Slowest: oral ingestion

CBD bioavailability generally refers to how quickly the CBD is enters your bloodstream and is made available to your body’s circulation system. The higher the bioavailabilty, the faster the CBD will take effect in your body and, likely, the stronger effect it will have on your body.

Though CBD contains a miniscule amount of THC, as mandated by federal law, some drug tests, depending on the equipment being used, may pick up the small amount of THC in CBD products.

No, it can be helpful for addressing pain, stress, and promoting general wellness, among other things. But we do not market our products as cures for medical ailments. If a CBD product claims to cure a medical condition, please be wary about purchasing those types of products.

The amount of CBD that you should take will depend on multiple factors, such as the type of CBD you are consuming, your age, weight, gender, medical history, personal preferences, etc. Please note that water soluble CBD has higher bioavailability and will likely have a stronger impact than non-nanoized water soluble CBD. Though this is not guidance specifically for you, we have seen many consumers take as little as 5mg of CBD and up to 150mg of CBD per day. We would recommend you consult your doctor regarding CBD dosage questions.

Pets may benefit from CBD for managing pain, inflammation, anxiety, stress, etc. There is a small but growing body of research of CBD usage for pets. If CBD is given to a pet, considering the likely difference in weight between you and your pet, please provide much smaller amounts of CBD to your pet than what you may be taking. Also, please note that dogs have a higher concentration of cannabinoid receptors in their bodies, which means that they will likely be more sensitive to CBD and other cannabinoids than humans. We recommend that you speak with your veterinarian before you start giving your pet CBD.

At Core Botanics, our focus is creating natural products for healthy lifestyles.  What sets us apart from other CBD companies is our foundation in science and cutting edge formulations from our in-house research and development team.

Project CBD has been collecting a growing body of scientific studies on CBD.


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If for any reason you are dissatisfied with any Core Botanics product, you may return that product to us within 90 days for a replacement, exchange, or full refund of the purchase price (excluding shipping).

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